Extreme Weight Loss is a television program from ABC in which individuals volunteer to receive training and lifestyle changes from trainer Chris Powell. The show is slightly based on the original concept of Extreme Makeover, where individuals receive life-changing makeovers. The exception is that this show focuses primarily on participants losing massive amounts of weight over one year and receiving plastic surgery to remove the excess skin from their transformations.

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Weighing in at 651 pounds, James, a 25-year-old former football player from Fort Worth, Texas, becomes the most obese person trainer and transformation specialist Chris Powell has ever worked with. James must lose 150 pounds to stay on track in the first of his four, three-month phases of weight loss.
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An ambitious 21-year-old woman who weighs nearly 400 pounds embarks on a one-year challenge in hope of losing weight.